Smartox Biotechnolgy的多肽毒素产品如下： 1. 作用于钠离子通道(Sodium channel)的毒素 Toxin nameCatalog #TargetPhrixotoxin-313PHX003Selective blocker of Nav1.2µ-conotoxin GIIIBCON020Selective blocker of Nav1.4µ-conotoxin CnIIICCON021Selective blocker of Nav1.4μ-conotoxin PIIIA08CON006Selective blocker of Nav1.4Jingzhaotoxin-III12JZH003Selective blocker of Nav1.5ProTx-II07PTX002Selective blocker of Nav1.7ProTx-II Biotin12PTB002Selective blocker of Nav1.7ProTx-I12PTX001Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7Huwentoxin-I07HWT001Blocker of TTX-SHuwentoxin-IV08HWT002Blocker of TTX-SHainantoxin-III13HTX003Blocker of TTX-SHainantoxin-IV12HTX001Blocker of TTX-SGsAF-I12GSF001Blocker of TTX-SGsAF-II12GSF002Blocker of TTX-S 2. 作用于钾离子通道(Potassium channel)的毒素 Toxin nameCatalog #TargetKCa channelsApamin 蜜蜂神经毒素08APA001SK1, SK2, SK3Charybdotoxin 蝎毒素11CHA001KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6Iberiotoxin12IBX001KCa1.1Leiurotoxin 1 (Scyllatoxin)10LEI001SK1, SK2, SK3Tamapin10TAM001SK1, SK2, SK3Kaliotoxin-108KTX002BK, Kv1.1, Kv1.2, Kv1.3Kv channelsShK08SHK001Kv1.3, Kv1.1, Kv1.4, Kv1.6TMR-ShKSAT001Kv1.3, Kv1.1Margatoxin08MAG001Kv1.3(Dap22)-ShK13SHD001Kv1.3ADWX-113ADW001Kv1.3HsTx108NEU001Kv1.3, Kv1.2Agitoxin-213AGI002Kv1.3, Kv1.1Maurotoxin08MAR001Kv1.2, KCa3.1Guangxitoxin 1E11GUA002Kv2.1, Kv2.2Stromatoxin 1 NEWSCT01Kv2.1, Kv2.2Kaliotoxin-108KTX002BK, Kv1.1, Kv1.2, Kv1.3Charybdotoxin11CHA001KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6Phrixotoxin-2PHX002Kv4.2, Kv4.3AmmTx3 NEWAMX001A-type potassium channelsInwardly rectifying potassium channelsTertiapinQ08TER001Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1hERG/Kv11.1BeKm-113BEK001ERG1 3. 作用于钙离子通道(Calcium channel)的毒素 Toxin nameCatalog #TargetHigh voltage-gated Ca2+ channelsω-agatoxin IVA11AGA001P/Qtypeω-Conotoxin MVIIC08CON002P/Qtype, N-typeω-Conotoxin MVIIA08CON001N-typeω-Conotoxin GVIA08CON003N-typeω-Conotoxin SO308CON013N-typeHuwentoxin I07HWT001N-typeProTx-II07PTX002T-type, L-typeIntermediate voltage-gated Ca2+ channelsSNX48208SNX002R-typeLow voltage-gated Ca2+ channelsProTx-I12PTX001T-typeProTx-II07PTX002T-type, L-typeRyanodine receptorsMaurocalcine07PAU001Ryr1 4. 作用于氯离子通道(Chloride channel)的毒素 Toxin nameCatalog #TargetChlorotoxin08CHL001Blocker of small conductance Cl- channelsGaTx113GTX001Selective blocker of CFTR channelGaTx210GTX002Selective blocker of ClC-2 channel 5. 作用于乙酰胆碱受体(Acetylcholine receptor)的毒素 Toxin nameCatalog #Targetα-conotoxin PeIA13CON017α9α10, α3β2 subunitsα-Conotoxin PrXA13CON016α1/β1/ε/δ, α1/β1/γ/δ subunitsWaglerin-112WAG001MusclenAChRα-conotoxin MI08CON012α1/δsubunitsα-conotoxin GI08CON005α/δsiteα-conotoxin IMI08CON011α7 homomeric nAChRα-conotoxin GIDCON019Blocker of α3β2, α7 and α4β2 nAChRs 6. 含N-甲基-D-天冬氨酸NR2B(NMDA, NR2B containing N-methyl-D-aspartate)Conantokin-G选择性、特异性抑制含NR2B的NMDAR。Conantokin-G能剂量依赖性抑制Ca2+内流，抑制NMDA诱导的兴奋性中毒效应。研究表明，在小鼠皮层神经元，Conantokin-G阻滞NMDA引发的电流信号的IC50值为480 nM。 7. 作用于酸敏感离子通道(ASIC channel, Acid-Sensing Ion Channel)的毒素 Toxin nameCatalog #TargetAPETx207APE002Selective blocker of ASIC3Psalmotoxin1/PcTx113PCT001Selective blocker of ASIC1aUgr9-113UGR001Blocker of ASIC3 8. 作用于瞬时受体电位(TRP channel, transient receptor potential)的毒素 Toxin nameCatalog #TargetGsMTx408GSM001TRPC, TRPAVanillotoxin310VAN003Activator of TRPV1ProTx-I12PTX001Antagonist of TRPA1 9. 作用于嘌呤能通道(Purinergic channel)的毒素Purotoxin-1选择性抑制P2X3受体。100 nM Purotoxin-1 (PT-1)选择性抑制P2X3受体通道，在大鼠DRG神经元上，使用膜片钳实验表明：PT-1对电压门控通道和TRPV1均无抑制效应。10 µM ATP和100 µM α,β Methylene-ATP浓度下Purotoxin-1对P2X3受体有选择性作用，在该ATP浓度下Purotoxin-1对P2X2和杂化二聚体P2X2/3并无激动作用。Purotoxin-1对疼痛的潜在治疗作用。 10. 作用于其它膜受体通道(Others)的毒素Smartox Biotechnology还提供其他类型的膜受体抑制剂： Toxin nameCatalog #TargetMorphiceptin011CAS001Agonist of µ-opoid receptorsLys-conopressin G11CON14Vasopressin-like peptideGsMTx408GSM001Mechano sensitive ion channelsObtustatin10OBT001Blocks the binding of α1β1  integrin to collagen IVRho-Conotoxin TIACON022Blocks α1-adrenergic receptor  公司简介Smartox Biotechnology是全球唯一一家专门生产动物毒液多肽毒素，用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。Smartox Biotechnology于2009年由来自Grenoble神经科学研究所(Grenoble Institute of Neuroscience)的Michel De Waard博士创立。Smartox Biotechnology专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为毒素）。De Waard博士研究离子通道与毒素多肽的关系，尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽(cell penetrating peptides, CPP)。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。2010年，Smartox Biotechnolgy被法国研究部(Ministry of Research)授予“新兴企业OSEO奖(OSEO prize for emerging businesses)”。总之，Smartox Biotechnolgy提供一系列高质量、具开创价值的多肽毒素。这些化合物在离子通道 研究中具有高的亲和性和选择性，是相应领域科学研究理想的生物毒素提供商和贴心的合作伙伴。

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